User Friendly Synthesis of Vogel’S Silyl Sulfinate and its Application in Quantitative GC–MS Analysis

Phosphorus, Sulfur, and Silicon and the Related Elements 2015
Irina Novosjolova, Māris Turks

The synthesis of trimethylsilyl 2-methylprop-2-ene-1-sulfinate (Vogel’s silyl sulfinate) from methallyltrimethylsilane and SO2 in the presence of Tf2NTMS was developed. The title compound silylates carbohydrates and other polyhydroxylated compounds by producing SO2 and isobutene as gaseous side products. This silylation procedure is perfectly suitable for derivatization and subsequent GC–MS quantitative analysis of ribose and malic acid as representatives of organic polyhydroxylated compounds.

Keywords
Trimethylsilyl 2-methylprop-2-ene-1-sulfinate; silylation; GC–MS derivatization; ribose; malic acid
DOI
10.1080/10426507.2014.996644
Hyperlink
http://www.tandfonline.com/doi/full/10.1080/10426507.2014.996644#.Ve1xd03otkQ

Novosjolova, I., Turks, M. User Friendly Synthesis of Vogel’S Silyl Sulfinate and its Application in Quantitative GC–MS Analysis. Phosphorus, Sulfur, and Silicon and the Related Elements, 2015, Vol.190, Iss.8, pp.1251-1256. ISSN 1042-6507. e-ISSN 1563-5325. Available from: doi:10.1080/10426507.2014.996644

Publication language
English (en)