Poly vinyl alcohol (PVA), is the largest synthetic water-soluble polymer produced in the world based on volume. It is produced commercially by the hydrolysis of poly vinyl acetate (PVAc). Composites prepared by blending of comparatively rigid poly vinyl alcohol (PVA) with rather compliant poly vinyl acetate (PVAc) show attractive strength-deformation characteristics which change significantly with PVA/PVAc proportions. To improve mechanical and other properties PVA is blended with different synthetic polymers. The aim of this study was to evaluate the influence of nanoparticles on the elastic modulus of PVA/PVAc blends by using response surface methodology (RSM). RSM include approximate model and the plan of experiments where the response has to be evaluated. A 3 level Full Factorial Design was employed for designing the plan of experiment.