Inhibitors of Selected Bacterial Metalloenzymes

Current Medicinal Chemistry 2019
Raivis Žalubovskis, J.-Y. Winum

The utilization of bacterial metalloenzymes, especially ones not having mammalian (human) counterparts, has drawn attention to develop novel antibacterial agents to overcome drug resistance and especially multidrug resistance. In this review, we focus on the recent achievements on the development of inhibitors of bacterial enzymes peptide deformylase (PDF), metallo-β-lactamase (MBL), methionine aminopeptidase (MetAP) and UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC). The state of the art of the design and investigation of inhibitors of bacterial metalloenzymes is presented, and challenges are outlined and discussed.

Keywords
Bacteria, Inhibitors, Metallo-β-lactamase, Metalloenzymes, Methionine aminopeptidase, Peptide deformylase, UDP-3-O-acylglucosamine deacetylase
DOI
10.2174/0929867325666180403154018
Hyperlink
http://www.eurekaselect.com/160962/article

Žalubovskis, R., Winum, J. Inhibitors of Selected Bacterial Metalloenzymes. Current Medicinal Chemistry, 2019, Vol. 26, No. 15, pp.2690-2714. ISSN 0929-8673. Available from: doi:10.2174/0929867325666180403154018

Publication language
English (en)