Hyaluronic Acid/Polylysine Composites for Local Drug Delivery: A Review

Key Engineering Materials. Vol.850: Materials Science and Applied Chemistry III: Selected peer-reviewed papers from 60th International Scientific Conference of Riga Technical University (RTU). Section of Materials Science and Applied Chemistry (MSAC 2019). 2020
Elīza Tračuma, Dagnija Loča

Site specific drug delivery systems (DDS) are usually developed to overcome the side effects of conventional ones (e.g. injections or oral ingestions), creating smart drug delivery vehicles characterized with greater efficiency, safety, predictable therapeutic response as well as controlled and prolonged drug release periods. DDS made of hyaluronic acid (HA) and poly-L-lysine (PLL) are promising candidates in the field of local drug delivery due to their high biocompatibility. Moreover, electrostatic attractions between negatively charged HA and positively charged PLL can be used to fabricate multilayer films, bilayer films and hydrogels, avoiding the application of toxic crosslinking agents. In this review, we report the preparation of HA/PLL composites exploiting their intrinsic properties, as well as developed composite application possibilities as controlled drug delivery systems in bone tissue, central nervous system and gene engineering.

Keywords
Drug Delivery, Hyaluronic Acid, Multilayer Film, Polyelectrolyte Complex, Polylysine
DOI
10.4028/www.scientific.net/KEM.850.213
Hyperlink
https://www.scientific.net/KEM.850.213

Tračuma, E., Loča, D. Hyaluronic Acid/Polylysine Composites for Local Drug Delivery: A Review. Key Engineering Materials, 2020, Vol. 850, pp.212-218. ISSN 1013-9826. e-ISSN 1662-9795. Available from: doi:10.4028/www.scientific.net/KEM.850.213

Publication language
English (en)