Sulfocoumarins as Dual Inhibitors of Human Carbonic Anhydrase Isoforms IX/XII and of Human Thioredoxin Reductase

Journal of Enzyme Inhibition and Medicinal Chemistry 2020
Mikhail Krasavin, Raivis Žalubovskis, Aiga Grandane, Ilona Domračeva, Petr Zhmurov, Claudiu T. Supuran

The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and–hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia and oxidative stress, may both contribute to the observed antiproliferative profile of these compounds against many cancer cell lines. This unprecedented dual anticancer mechanism may lead to a new approach for designing innovative therapeutic agents.

Keywords
Anticancer agents, carbonic anhydrase inhibition, hypoxia, oxidative stress, thioredoxin reductase inhibition
DOI
10.1080/14756366.2020.1712596
Hyperlink
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1712596

Krasavin, M., Žalubovskis, R., Grandane, A., Domračeva, I., Zhmurov, P., Supuran, C. Sulfocoumarins as Dual Inhibitors of Human Carbonic Anhydrase Isoforms IX/XII and of Human Thioredoxin Reductase. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, Vol. 35, No. 1, pp.506-510. ISSN 1475-6366. e-ISSN 1475-6374. Available from: doi:10.1080/14756366.2020.1712596

Publication language
English (en)