Synthesis of Tetrazolo[1,5-c]quinazoline Derivatives

Latvijas Universitātes 79. starptautiskā zinātniskā konference. Ķīmijas sekcija: tēžu krājums 2021
Andris Jeminejs, Ērika Bizdēna, Irina Novosjolova

Quinazoline core is a privileged molecular scaffold, which has already been proven as an effective tool in the treatment of different types of cancer. Our group recently reported unorthodox arylsulfanyl group dance around quinazoline core, leading to novel 5(arylthio)tetrazolo[1,5-c]quinazolines. This paves a path for the synthesis of modified compounds that, otherwise requiring complex synthetic approaches, can be easily acquired with good to excellent yields.

Keywords
Quinazoline, azide, tautomeric equilibrium, sNAr, click chemistry
Hyperlink
https://www.kf.lu.lv/fileadmin/user_upload/LU.LV/Apaksvietnes/Fakultates/www.kf.lu.lv/79_konf_programma/KF_79_konf_Tezes_2021_.pdf

Jeminejs, A., Bizdēna, Ē., Novosjolova, I. Synthesis of Tetrazolo[1,5-c]quinazoline Derivatives. In: Latvijas Universitātes 79. starptautiskā zinātniskā konference. Ķīmijas sekcija: tēžu krājums, Latvia, Riga, 5-5 February, 2021. Rīga: Latvijas Universitāte, 2021, pp.57-57. ISBN 978-9934-18-649-3.

Publication language
English (en)