An important consequence of development of transport complex of country is a growth of economic and social well-being of population. Focus on optimally functioning transport should be considered as an important factor in sustainable economic development, and deviations from optimal values as an indicator of additional reserves for growth. Defining national economic interests is one of the main tasks of Ukraine's development. In order to develop independently, and at the same time on the basis of partnership and cooperation, it is necessary to develop transport provision for the regions and interregional integration to form a whole transport space. The author's approach in considering this problem using general scientific and special methods of scientific research made it possible to investigate these processes. The article describes a methodological approach to the study of the transportation in the regions of Ukraine on the basis of intermodality and multimodality using forms of scientific - technical and static analysis, which will contribute to the implementation of the state policy of interregional integration, taking into account freight transportation using various types of transport. A scientific and applied approach has been proposed for determining the interdependence of the gross regional product per person on the freight turnover by kind of transport by using the methodological tools of the system analysis theory in order to identify transport regions and efficiently locate multimodal terminals (transport hubs), which will contribute to the implementation of effective instruments to promote interregional integration and regional economic integration, information, education spaces into a single transport space, overcoming interregional alienation and the introduction of effective instruments of state support for interregional integration, will contribute to the implementation of interregional programs and projects.