Azide-tetrazole Tautomeric Equilibrium Controlled Synthesis of Inverted Tetrazolo[1,5-a/c]quinazolines

27th Croatian Meeting of Chemists and Chemical Engineers: Book of Abstracts 2021
Andris Jeminejs, Svetlana Marija Goliškina, Irina Novosjolova, Ērika Bizdēna

Quinazoline core is an example of privileged molecular scaffolds, which has already been proven as an effective tool in the treatment of different types of cancer.[1] We report unorthodox arylsulfanyl group dance around quinazoline core, leading to a variety of 5-substituted tetrazolo[1,5-c]quinazolines 3 and 4.[2] On the other hand, inverted 5-substituted tetrazolo- [1,5-a]quinazolines 6 can be obtained via regioselective SNAr reaction of tautomerically locked 2,4-diazidoquinazoline 5.

Keywords
quinazoline, azide-tetrazole equilibrium
Hyperlink
https://27hskiki.hkd.hr/book-of-abstracts/

Jeminejs, A., Goliškina, S., Novosjolova, I., Bizdēna, Ē. Azide-tetrazole Tautomeric Equilibrium Controlled Synthesis of Inverted Tetrazolo[1,5-a/c]quinazolines. In: 27th Croatian Meeting of Chemists and Chemical Engineers: Book of Abstracts, Croatia, Veli Lošinj, 5-8 October, 2021. Zagreb: Croatian Chemical Society, 2021, pp.112-112. e-ISSN 2757-0754.

Publication language
English (en)