Injectable Hyaluronic Acid/ɛ-Polylysine Hydrogels Loaded with Strontium Hydroxyapatite Nanoparticles for Osteoporotic Bone Fracture Healing
33rd Annual Conference of the European Society for Biomaterials (ESB 2023): Conference Abstracts 2023
Anna Rubīna, Anastasija Tumiloviča, Artemijs Ščeglovs, Līga Stīpniece, Kristīne Šalma-Ancāne

Osteoporosis causes bone fractures and large irregular shape bone defects, which are usually treated with bone auto/allografts, inert metallic implants or bioactive ceramic implants. These approaches have numerous limitations, like insufficient availability, disease transmission, infection and brittleness. Therefore, there is a need for novel injectable, antibacterial, bioactive biomaterials for filling osteoporotic bone defects. The aim of this study was to synthesize and characterize composite hydrogels based on natural biopolymers ɛ-polylysine (ɛ-PL) and hyaluronic acid (HA), and strontium substituted hydroxyapatite nanoparticles (Sr-nHAp). The developed ɛ-PL-HA/Sr-nHAp composite hydrogel has great potential to be used as an injectable bioactive biomaterial for osteoporotic bone regeneration. Further studies need to be conducted on Ca2+ and Sr2+ ion release kinetics, cell viability and antibacterial activity to determine the full biomedical potential of this biomaterial.


Keywords
Hydrogels

Rubīna, A., Tumiloviča, A., Ščeglovs, A., Stīpniece, L., Šalma-Ancāne, K. Injectable Hyaluronic Acid/ɛ-Polylysine Hydrogels Loaded with Strontium Hydroxyapatite Nanoparticles for Osteoporotic Bone Fracture Healing. In: 33rd Annual Conference of the European Society for Biomaterials (ESB 2023): Conference Abstracts, Switzerland, Davos, 4-8 September, 2023. Davos: ARI Abstracts Periodical, 2023, pp.565-565.

Publication language
English (en)
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