Synthesis of Pyridinium Moiety Containing Triazolyl Purines
Molbank 2024
Aleksejs Burcevs, Māris Turks, Irina Novosjolova

Pyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives in water. Target structures were obtained using the tosylation of hydroxyl groups of 2-(6-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-2-(piperidin-1-yl)-9H-purin-9-yl)propane-1,3-diol, the subsequent introduction of pyridine, and ion exchange. The compounds were characterized using 1H- and 13C-NMR spectra, FTIR, UV–Vis, and HRMS data.


Keywords
purines, triazoles, pyridinium salts
DOI
10.3390/M1855
Hyperlink
https://www.mdpi.com/1422-8599/2024/3/M1855

Burcevs, A., Turks, M., Novosjolova, I. Synthesis of Pyridinium Moiety Containing Triazolyl Purines. Molbank, 2024, Vol. 2024, No. 3, Article number M1855. e-ISSN 1422-8599. Pieejams: doi:10.3390/M1855

Publication language
English (en)
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