Demand side management commonly is used to manage energy consumption for optimization of available or planned energy generation resources. Since regional level is found as the most appropriate energy planning level for promotion of renewable energy sources and for reduction of environmental impacts, the aim of research was to develop a system for implementation of demand side management at regional level and elaborate the screening methodology for selection of most appropriate options for improvements. Regional demand side management system was developed and tested based on energy structure of typical rural middle-sized region in Latvia. Elaborated screening methodology is based on theoretical and practical basics on decision-making.