Photoredox-catalyzed direct C–H monofluoromethylation of heteroarenes

Nagarajan Ramkumar, Ketrina Plantus, Melita Ozola, Anatoly Mishnev, Vizma Nikolajeva, Maris Senkovs, Maksim Ošeka, Jānis Veliks

S2 Table of Contents 1. General Information ....................................................................................................................... 3 2. Synthesis of phenyl-λ3-iodanediyl bis(2-fluoroacetate) .................................................................. 4 2.1 Differential scanning calorimetry and Thermogravimetric analysis of reagent (2) .................... 5 2.2 Cyclic voltammetry...................................................................................................................... 5 3. General procedures for the synthesis of starting materials ........................................................... 7 4. Optimization of the reaction conditions ....................................................................................... 15 5. Mechanistic investigations............................................................................................................ 18 6. General procedure for CH radical monofluoromethylation of heteroarenes ............................ 27 7. Synthetic applications ................................................................................................................... 29 7.1 Sun-light driven reaction........................................................................................................... 29 7.2 Procedure for the Scale-up experiment in Continuous flow .................................................... 30 8. Evaluation of anti-microbial activity ............................................................................................. 31 9. Evaluation of anti-cancer activity.................................................................................................. 33 10. X-ray crystal structures of products .......................................................................................... 36 11. References ................................................................................................................................ 42 12. Characterization data................................................................................................................ 44 13. Copies of 1H, 19F and 13C spectra ..............................................................................................

Pieteikuma datums
16.10.2024.
Atslēgas vārdi
Photoredox-catalyzed direct C–H monofluoromethylation of heteroarenes
Hipersaite
https://www.rsc.org/suppdata/d3/nj/d3nj04313d/d3nj04313d1.pdf