Effect of the Solvent Nature on the Course of Quaternization of 3,5-Diethoxycarbonyl-2,6-Dimethyl-4-(3-Pyridyl)-1,4-Dihydropyridine

Chemistry of Heterocyclic Compounds 2011
K. Pajuste, M. Gosteva, D. Kaldre, Māra Plotniece, B. Cekavicus, A. Sobolev, A. Priksane, G. Tirzitis, G. Duburs, A. Plotniece

The effect of solvent nature and temperature on the quaternization of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine by lipophilic alkyl bromides has been investigated. By comparision of the solvent effect (acetone, acetonitrile,2-butanone) on the alkylation of the pyridine fragment of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-DHP it was established that conducting the reaction in acetonitrile ar 81 degree is the most optimal.

Atslēgas vārdi
acetone, acetonitrile, 2-butanone, 1,4-DHP, Pyridinium derivatives
DOI
10.1007/s10593-011-0803-3
Hipersaite
http://link.springer.com/article/10.1007%2Fs10593-011-0803-3?LI=true

Pajuste, K., Gosteva, M., Kaldre, D., Plotniece, M., Cekavicus, B., Sobolev, A., Priksane, A., Tirzitis, G., Duburs, G., Plotniece, A. Effect of the Solvent Nature on the Course of Quaternization of 3,5-Diethoxycarbonyl-2,6-Dimethyl-4-(3-Pyridyl)-1,4-Dihydropyridine. Chemistry of Heterocyclic Compounds, 2011, Vol.47, Iss.5, 597.-601.lpp. ISSN 0009-3122. e-ISSN 1573-8353. Pieejams: doi:10.1007/s10593-011-0803-3

Publikācijas valoda
English (en)