The goal of this study is the evaluation of effectiveness of various control modes of variable speed centrifugal pumps for use in different parts of a district heating system. For this reason, the regression equations with the coefficients of determination have been derived. As a result, the trend of energy consumption reduction has been determined when the proportional pressure control mode is used, in comparison with the constant differential pressure control mode. The change of the efficiency level of centrifugal pumps of various designs has been also investigated in the article. It has been done at different values of the nominal flow and head when the constant flow control mode is used.