Wettability of the poly methyl methacrylate (PMMA) surface defines its biocompatibility being essential factor for biomedical applications. The processed surface degrades in time therefore the prostheses/lens should be repaired to keep the patient at a high life quality level. However the most common methods can be considered as sophisticated (plasma treatment, laser treatment, etc.). The research presents novel result on the PMMA surface wettability engineering by means of non-ionizing ultraviolet radiation (200-400nm). Results (electron work function (), photoelectron emission spectra, optical absorption) show alteration from hydrophobic to hydrophilic surface behaviour. Both the surface (photoelectron emission) and the bulk (optical absorption) interacting centres were influenced by radiation showing maximum effect after 45 minutes of irradiation.