Droplet processing technologies and many biological processes use disk-like or hemispherical shapes for construction or the design of surfaces. The ability to tune the characteristics and properties of a surface is important at the micro- and nano-scale. The influence of size on the mechanical properties is presently unknown. This work set out to produce splats from different droplet sizes (20–40 micron, 40–60 micron and 60–80 micron), and then determine the deposit characteristics and mechanical properties. All splats produced by melting particles in a flame and depositing onto a polished titanium surface were amorphous, as determined by Raman micro-spectrometry. The topography shown in an optical and scanning electron microscope and topographically mapped using the scanning mode of the nano-indenter revealed a flattened hemispherical deposit. The critical nano indentation loadf or determining the true hardness decreased with increasing splat size; for 20–40 micron, 40–60 micron and 60–80 micron splats the critical load was 19, 16, 11 mN respectively compared to 30mN for sintered hydroxyapatite. Higher loads are required to cause cracking and delimitation in smaller splats. A load between 40 and 60 mN was required for delimitation of the splat. Delamination of the splats could offer a new means to determine the adhesion of splats on low roughness surfaces.