Gene Delivery Agents Possessing Antiradical Activity: Self-Assembling Cationic Amphiphilic 1,4-Dihydropyridine Derivatives

New Journal of Chemistry 2013
Kārlis Pajuste, Zanna Hyvonen, Oksana Petricenko, Dainis Kaldre, Martins Rucins, Brigita Cekavicus, Velta Ose, Baiba Skrivele, Marina Gosteva, Emmanuelle Morin-Picardat, Māra Plotniece, Arkadij Sobolev, Gunārs Duburs, Marika Ruponen, Aiva Plotniece

Seventeen 1,4-dihydropyridine amphiphiles including diferently substituted pyridinium, pyrazinium, N-methyl piperidinium or N-methyl morpholinium moieties as the cationic head-group of the molecule have been designed and synthesized. The ability of the 1,4-dihydropyridine amphiphiles to self-assemble, to bind pDNA and to transfer it into the cells as well as the cytotoxicity of 1,4-DHP amphiphile-pDNA complexes was studied.

Atslēgas vārdi
gene delivery agents, cationic 1,4-DHP amphiphiles
DOI
10.1039/C3NJ00272A
Hipersaite
https://pubs.rsc.org/en/content/articlelanding/2013/NJ/c3nj00272a#!divAbstract

Pajuste, K., Hyvonen, Z., Petricenko, O., Kaldre, D., Rucins, M., Cekavicus, B., Ose, V., Skrivele, B., Gosteva, M., Morin-Picardat, E., Plotniece, M., Sobolev, A., Duburs, G., Ruponen, M., Plotniece, A. Gene Delivery Agents Possessing Antiradical Activity: Self-Assembling Cationic Amphiphilic 1,4-Dihydropyridine Derivatives. New Journal of Chemistry, 2013, Vol. 37, No. 10, 3062.-3075.lpp. ISSN 1144-0546. e-ISSN 1369-9261. Pieejams: doi:10.1039/C3NJ00272A

Publikācijas valoda
English (en)