Synthesis of Novel Unsymmetrically Substituted 1,4-Dihydroisonicotinic Acid and its Derivatives

Химия гетероциклических соединений 2013
Inguna Goba, B. Turovska, Sergejs Beļakovs, Edgars Liepiņš

The synthesis of new unsymmetrically substituted 1,4-dihydroisonicotinic acid bearing cyano and acetyl groups in positions 3 and 5 of the heterocycle has been developed. The methyl, ethoxycarbonylmethyl, and propionyloxymethyl esters of the acid have been obtained. The method of N-alkylation reaction of synthesized 1,4-dihydroisonicotinic acid esters has been elaborated.

Goba, I., Turovska, B., Beļakovs, S., Liepiņš, E. Synthesis of Novel Unsymmetrically Substituted 1,4-Dihydroisonicotinic Acid and its Derivatives. Химия гетероциклических соединений, 2013, No. 5, 778.-787.lpp. ISSN 0132-6244.

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