Synthesis of Novel Bispyridinium-1,4-Dihydropyridine Dibro¬Mi¬Des and Evaluation of Their Antiradical Activity and Reducing Capacity
Assets of Chemistry in Drug Discovery: 21st Young Research Fellow Meeting (XXIemes Journées Jeunes Chercheurs SCT)
2014
Martins Rucins,
Marina Gosteva,
Sergejs Beļakovs,
Arkadij Sobolev,
Kārlis Pajuste,
Māra Plotniece,
Brigita Cekavicus,
Dace Tirzīte,
Aiva Plotniece
New bispyridinium dibromides on the 1,4-DHP core were synthesized in the reaction between 4-pyridyl-1,4-DHP derivatives and propargyl bromide. The antiradical activity using the 1,1-diphenyl-2-picrylhydrazine free radicals scavening and reducing capacity using phosphomolybdenum complexmethods of newly synthesized compounds have been evaluated.
Atslēgas vārdi
1,4-DHP, antiradical activity, propargyl bromide
Rucins, M., Gosteva, M., Beļakovs, S., Sobolev, A., Pajuste, K., Plotniece, M., Cekavicus, B., Tirzite, D., Plotniece, A. Synthesis of Novel Bispyridinium-1,4-Dihydropyridine Dibro¬Mi¬Des and Evaluation of Their Antiradical Activity and Reducing Capacity. No: Assets of Chemistry in Drug Discovery: 21st Young Research Fellow Meeting (XXIemes Journées Jeunes Chercheurs SCT), Francija, Montpellier, 24.-25. marts, 2014. Montpellier: 2014, 58.-58.lpp.
Publikācijas valoda
English (en)