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Publikācija: Cinnamic Acid Hydrogen Bonds to Isoniazid and N'-(Propan-2-Ylidene)Isonicotinohydrazide

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā Cinnamic Acid Hydrogen Bonds to Isoniazid and N'-(Propan-2-Ylidene)Isonicotinohydrazide, an in situ Reaction Product of Isoniazid and Acetone
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.4. Ķīmija
Autori I. Sarcevica
Liāna Orola
M.V. Veidis
Sergejs Beļakovs
Atslēgas vārdi cinnamic acid–isoniazid cocrystal; crystal structure; hydrogen bonding; in situ modification; modification of hydrogen bonding; pharmaceutically active compound
Anotācija A new polymorph of the cinnamic acid-isoniazid cocrystal has been prepared by slow evaporation, namely cinnamic acid-pyridine-4-carbohydrazide (1/1), C9H8O2·C6H7N3O. The crystal structure is characterized by a hydrogen-bonded tetrameric arrangement of two molecules of isoniazid and two of cinnamic acid. Possible modification of the hydrogen bonding was investigated by changing the hydrazide group of isoniazid via an in situ reaction with acetone and cocrystallization with cinnamic acid. In the structure of cinnamic acid-N'-(propan-2-ylidene)isonicotinohydrazide (1/1), C9H8O2·C9H11N3O, carboxylic acid-pyridine O-H···N and hydrazide-hydrazide N-H···O hydrogen bonds are formed.
DOI: 10.1107/S2053229614003684
Hipersaite: http://onlinelibrary.wiley.com/doi/10.1107/S2053229614003684/abstract 
Atsauce Sarcevica, I., Orola, L., Veidis, M., Beļakovs, S. Cinnamic Acid Hydrogen Bonds to Isoniazid and N'-(Propan-2-Ylidene)Isonicotinohydrazide, an in situ Reaction Product of Isoniazid and Acetone. Acta Crystallographica Section C, 2014, Vol.70, Iss.4, 392.-395.lpp. e-ISSN 2053-2296. Pieejams: doi:10.1107/S2053229614003684
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ID 19212