Welcome to the 16th Edition of the International Conference on Harbor, Maritime and Multimodal Logistics Modeling & Simulation, HMS 2014! At global scale, logistics is continuously reshaping itself under the pressure of different technologies and trends. Indeed, from one side we can easily understand that logistics stakeholders need to decide how and when adopting new technologies suchas mobile devices and applications, internet of everything, new sensors and embedded technologies, sustainable transportation solutions etc. From the other side, they are continuously pushed to increase their efficiency to satisfy multiple (and sometime conflicting) requirements: to cite a few, consumerism, sustainability, financial crises, new developing countries, massive urbanization, etc. In such a context, the goal of the HMS conference is to understand how and to which extent the “logistics change” can be supported by Modeling & Simulation. Over the year, Modeling & Simulation has already proved to be one of the most suitable approaches to support both training and decision support in logistics and supply chain; and nowadays the role of Modeling & Simulation is becoming even more important thanks to the evolution of the concept of “Simulation as a Service”.