Evaluation of Antiradical Activity and Reducing Capacity of Synthesized Bispyridinium Dibromides Obtained by Quaternisation of 4-Pyridyl-1,4-dihydropyridines with Propargyl Bromide
Australian Journal of Chemistry 2015
Martins Rucins, Marina Gosteva, Sergejs Beļakovs, Arkadij Sobolev, Kārlis Pajuste, Māra Plotniece, Brigita Cekavicus, Dace Tirzīte, Aiva Plotniece

New bispyridinium dibromides based on the 1,4-dhydropyridine (1,4-DHP) cycle were synthesized in the reaction between 4-pyridyl-1,4-DHP derivatives and propargylbromide. It has been shown that variation of the substituent position on the pyridine as well as changes in the electronic nature of the 1,4-DHP cycle as a result of the substituent nature at the 3 and 5 positions do not affect the course of the reaction and in all cases the corresponding bispyridinium dibromides were formed. The antiradical activity, using 1,1-diphenyl-2-picrylhydrazine as a free radical scavenger, and the reducing capacity using phosphomolybdenum complexes have been evaluated for the newly synthesized compound. It has been shown that all tested 1,4-DHP bispyridinium dibromides possess reducing capacity and antiradical properties.


Atslēgas vārdi
1,4-DHP, quaternisation, antiradical activity, reducing capacity
DOI
10.1071/CH14033
Hipersaite
http://www.publish.csiro.au/ch/CH14033

Rucins, M., Gosteva, M., Beļakovs, S., Sobolev, A., Pajuste, K., Plotniece, M., Cekavicus, B., Tirzīte, D., Plotniece, A. Evaluation of Antiradical Activity and Reducing Capacity of Synthesized Bispyridinium Dibromides Obtained by Quaternisation of 4-Pyridyl-1,4-dihydropyridines with Propargyl Bromide. Australian Journal of Chemistry, 2015, Vol.68, No.1, 86.-92.lpp. ISSN 0004-9425. e-ISSN 1445-0038. Pieejams: doi:10.1071/CH14033

Publikācijas valoda
English (en)
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