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Publikācija: Crystallized Nano-Sized Alpha-Tricalcium Phosphate from Amorphous Calcium Phosphate: Microstructure

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā Crystallized Nano-Sized Alpha-Tricalcium Phosphate from Amorphous Calcium Phosphate: Microstructure, Cementation and Cell Response
Pētniecības nozare 2. Inženierzinātnes un tehnoloģijas
Pētniecības apakšnozare 2.4. Ķīmijas inženierzinātne
Autori Linda Vecbiškena
Kārlis-Agris Gross
Una Riekstiņa
Thomas Chung-Kuang Yang
Atslēgas vārdi amorphous calcium phosphate, alpha tricalcium phosphate, Rietveld refinement, cell response, bone cements, regenerative medicine
Anotācija New insight on the conversion of amorphous calcium phosphate (ACP) to nano-sized alpha tricalcium phosphate (α-TCP) provides a faster pathway to calcium phosphate bone cements. In this work, synthesized ACP powders were treated with either water or ethanol, dried, crystallized between 700 and 800 °C, and then cooled at different cooling rates. Particle size was measured in a scanning electron microscope, but crystallite size calculated by Rietveld analysis. Phase composition and bonding in the crystallized powder was assessed by x-ray diffraction and Fourier-transform infrared spectroscopy. Results showed that 50 nm sized α-TCP formed after crystallization of lyophilized powders. Water treated ACP retained an unstable state that may allow ordering to nanoapatite, and further transition to β-TCP after crystallization and subsequent decomposition. Powders treated with ethanol, favoured the formation of pure α-TCP. Faster cooling limited the growth of β-TCP. Both the initial contact with water and the cooling rate after crystallization dictated β-TCP formation. Nano-sized α-TCP reacted faster with water to an apatite bone cement than conventionally prepared α-TCP. Water treated and freeze-dried powders showed faster apatite cement formation compared to ethanol treated powders. Good biocompatibility was found in pure α-TCP nanoparticles made from ethanol treatment and with a larger crystallite size. This is the first report of pure α-TCP nanoparticles with a reactivity that has not required additional milling to cause cementation.
DOI: 10.1088/1748-6041/10/2/025009
Hipersaite: http://iopscience.iop.org/1748-605X/10/2/025009/ 
Atsauce Vecbiškena, L., Gross, K., Riekstiņa, U., Chung-Kuang Yang, T. Crystallized Nano-Sized Alpha-Tricalcium Phosphate from Amorphous Calcium Phosphate: Microstructure, Cementation and Cell Response. Biomedical Materials, 2015, Vol.10, No.2, 1.-10.lpp. ISSN 1748-6041. e-ISSN 1748-605X. Pieejams: doi:10.1088/1748-6041/10/2/025009
Papildinformācija Citējamību skaits:
ID 20168