Synthesis of Novel 3-Substituted Benzamides Related to Imatinib

Journal of Chemical Research 2016
Svetlana Terentjeva, Dzintra Muceniece, Jekaterina Petushkova, Viesturs Lūsis

Twelve new 3-substituted benzamide derivatives structurally related to tyrosine kinase inhibitor imatinib have been synthesised by a Cu(I)-catalysed coupling of three previously synthesised (5-iodo-2-methylphenyl)-[4-(pyridin-3-yl)-6-perfluoroalkylpyrimidin-2-yl]amines with four synthesised 3-substituted 4-(4-methylpiperazin-1-ylmethyl)benzamides.

Atslēgas vārdi
(6-PERFLUOROALKYLPYRIMIDIN-2-YL)AMINES; 3,4-SUBSTITUTED BENZAMIDES; CU(I) CATALYSED COUPLING
DOI
10.3184/174751916X14576998046299
Hipersaite
http://www.ingentaconnect.com/content/stl/jcr/2016/00000040/00000004/art00008

Terentjeva, S., Muceniece, D., Petushkova, J., Lūsis, V. Synthesis of Novel 3-Substituted Benzamides Related to Imatinib. Journal of Chemical Research, 2016, Vol.40, No.4, 193.-225.lpp. ISSN 1747-5198. Pieejams: doi:10.3184/174751916X14576998046299

Publikācijas valoda
English (en)