This book contains the proceedings of the 6th International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2016), which is sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC) and held in cooperation with the ACM SIGSIM - Special Interest Group on Simulation and Modeling, the Movimento Italiano Modellazione e Simulazione (MIMOS), The Federation of European Simulation Societies (EUROSIM), the Society for the Study of Artificial Intelligence and Simulation of Behaviour (AISB), the European Council for Modeling and Simulation (ECMS), the International Association for Mathematics and Computers in Simulation (IMACS), the AIS Special Interest Group on Modeling and Simulation (AIS SIGMAS), the European Training and Simulation Association (ETSA), the Latvian Simulation Society (LSS), the Bulgarian Modeling and Simulation Association (BULSIM), the Federation of Asia Simulation Societies (ASIASIM) and the Japan Society for Simulation Technology (JSST). The conference it is also technically co-sponsored by the Liophant Simulation, the Simulation Team, the IEEE Computer Society (IEEE CS) and the Technical Committee on Simulation (IEEE CS - TCSIM). This conference, which is the sixth in a row, has again met with much interest of the research community worldwide, which is the best proof that, first, the idea of the SIMULTECH conferences that has been conceived some years ago by a group of dedicated people with vision has been a proper choice. And, second, that the research and scholarly community working in the field of broadly perceived simulation has responded with great interest in spite of such an abundance of conferences on all possible topics that we presently face.