Welcome to the 18th International Conference on Harbor, Maritime & Multimodal Logistics and Simulation (HMS 2016), that is a great opportunity for worldwide scientists and experts to share experiences, recent research efforts, studies and applications related to maritime environments, logistics and supply chain management issues. Within this framework the papers selected for publication in the HMS 2016 proceedings cover different areas and they have been organized in multiple sessions such as Simulation Airports design and Management, Modeling & Simulation in Logistics, Intermodal Transportation Systems and Services. Furthermore, some of the articles have been scheduled as part of joint sessions (with the other I3M 2016 conferences) because they focus specific applications including Logistics in Defense and Homeland Security as well as Human Behavior Management.