Understanding of domain phenomena and their interrelations is necessary for successful software development. The knowledge frame system based on principles of Topological Functioning Modelling (TFM) can be used for this purpose at the Computation Independent level within Model Driven Development. Research on knowledge formats showed that inferring in the closed world paradigm and similarity to the object-oriented paradigm made frames an attractive candidate to the knowledge representation format. Frames can hold information necessary for generation of the TFM. The knowledge system based on the principles of the TFM does not allow inferring ambiguous facts and leads to the more complete discovery of knowledge.