Method development in chromatography can be considered as a process studying the empirical relationships between the quality of a chromatogram and the chromatographic conditions. A chromatographer changes conditions to find an acceptable method to achieve a separation in a reasonable time. The time required to find optimal conditions or to make any conclusion can be substantially reduced by using computer programs for method development. HPLC method development programs can be utilized interactively (off-line) and for automatic optimization (on-line). ChromSword for off-line computer assisted method development was launched in 1994 as an extension of ChromDream software [1]. In 1998 – 2000 the first version for unattended method development started [2]. The latest version of ChromSword combines different technologies of method development in one software platform.