Power plants operators are persuaded to operate the main equipment such as centrifugal pumps in economically effective way. The operation of pump sets of district heating network at power plants should be done according to prescriptions of the original equipment manufacturer with further implementation of these requirements to distributed control system of the plant. In order to operate industrial pump sets with a small number of malfunctions is necessary to control the duty point of pump sets in H-Q coordinates, which could be complex task in some installations. Alternatively, pump operation control could be organized in H-n (head vs rpm) coordinates, utilizing pressure transmitters in pressure pipeline and value of rpm from variable speed driver. Safe operation range of the pump has to be limited with system parabolas, which prevents the duty point location outside of the predefined operation area. The particular study demonstrates the engineering approach for pump’s safe operation control development in MATLAB /Simulink environment, which allows to simulate the operation of the pump at different capacities in hydraulic system with variable characteristic and to predefine the conditions for efficient simultaneous pump operation in parallel connection.