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Publikācija: Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1

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Publikācijas valoda English (en)
Nosaukums oriģinālvalodā Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines
Pētniecības nozare 1. Dabaszinātnes
Pētniecības apakšnozare 1.4. Ķīmija
Pētniecības platforma Neviena
Autori Pavels Dimitrijevs
Martins Rucins
Māra Plotniece
Kārlis Pajuste
Ludmila Jackevica
Anita Gulbe
Signe Kibilda
Arkadijs Sobolevs
Janis Liepins
Ilona Domracheva
Dace Bandere
Aiva Plotniece
Atslēgas vārdi 1,4-DHP, lipid-like, cytotoxicity, toxicity, propargylgroup
Anotācija Design of nanoparticle delivery materials possessing biological activity is ideal strategy for therapies. Cationic 1,4-dihydropyridines capable to transfecting pDNA into cells were developed by Institute of Organic Synthesis. It was demonstrated that cationic 1,4-DHP showed high transfection efficiencies. In this work we studied properties of 4-(N-alkylpyridinium)-1,4-DHP containing propargylgroup: evaluated self-assembling properties, nanoparticles size distribution and stability, determined critical micelle formation concentration. Interaction of 1,4-DHP`s with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine model membranes has been demonstrated. Cytotoxicity/toxicity of 4-(N-alkylpyridinium)-1,4-DHP`s has been evaluated.
Atsauce Dimitrijevs, P., Rucins, M., Plotniece, M., Pajuste, K., Jackevica, L., Gulbe, A., Kibilda, S., Sobolevs, A., Liepins, J., Domracheva, I., Bandere, D., Plotniece, A. Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines. No: Riga Stradiņš University International Conference "Knowledge for Use in Practice": Abstract Book, Latvija, Riga, 1.-3. aprīlis, 2019. Riga: RSU, 2019, 412.-412.lpp. ISBN 978-9934-563-29-4.
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ID 29073