Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines
Riga Stradiņš University International Conference "Knowledge for Use in Practice": Abstract Book 2019
Pavels Dimitrijevs, Martins Rucins, Māra Plotniece, Kārlis Pajuste, Ludmila Jackevica, Anita Gulbe, Signe Kibilda, Arkadijs Sobolevs, Janis Liepins, Ilona Domracheva, Dace Bandere, Aiva Plotniece

Design of nanoparticle delivery materials possessing biological activity is ideal strategy for therapies. Cationic 1,4-dihydropyridines capable to transfecting pDNA into cells were developed by Institute of Organic Synthesis. It was demonstrated that cationic 1,4-DHP showed high transfection efficiencies. In this work we studied properties of 4-(N-alkylpyridinium)-1,4-DHP containing propargylgroup: evaluated self-assembling properties, nanoparticles size distribution and stability, determined critical micelle formation concentration. Interaction of 1,4-DHP`s with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine model membranes has been demonstrated. Cytotoxicity/toxicity of 4-(N-alkylpyridinium)-1,4-DHP`s has been evaluated.


Atslēgas vārdi
1,4-DHP, lipid-like, cytotoxicity, toxicity, propargylgroup

Dimitrijevs, P., Rucins, M., Plotniece, M., Pajuste, K., Jackevica, L., Gulbe, A., Kibilda, S., Sobolevs, A., Liepins, J., Domracheva, I., Bandere, D., Plotniece, A. Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines. No: Riga Stradiņš University International Conference "Knowledge for Use in Practice": Abstract Book, Latvija, Riga, 1.-3. aprīlis, 2019. Riga: RSU, 2019, 412.-412.lpp. ISBN 978-9934-563-29-4.

Publikācijas valoda
English (en)
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