Sulfocoumarins, Specific Carbonic Anhydrase IX and XII Inhibitors, Interact with Cancer Multidrug Resistant Phenotype through pH Regulation and Reverse P-glycoprotein Mediated Resistance

European Journal of Pharmaceutical Sciences 2019
Ana Podolski-Renic, Jelena Dinić, Tijana Stanković, Mirna Jovanovic, Amra Ramović, Aleksandrs Pustenko, Raivis Žalubovskis, Milica Pešic

New 6-triazolyl-substituted sulfocoumarins were described as potent inhibitors of the transmembrane human carbonic anhydrase isoforms, CAIX and CAXII. These membrane associated enzymes that maintain pH and CO2 homeostasis are involved in cancer progression, invasion, and resistance to therapy. Recently, it was shown that CAXII expression associates with the expression of P-glycoprotein in multidrug resistant cancer cells. CAXII regulates P-glycoprotein activity by maintaining high intracellular pHi. In this study, the activity of three new sulfocoumarins was evaluated in three sensitive and corresponding multidrug resistant cancer cell lines with increased P-glycoprotein expression (non-small cell lung carcinoma, colorectal carcinoma and glioblastoma).

Atslēgas vārdi
sulfocoumarins, carbonic anhydrase, triazole
DOI
10.1016/j.ejps.2019.105012
Hipersaite
https://www.sciencedirect.com/science/article/pii/S0928098719302751?via%3Dihub

Podolski-Renic, A., Dinić, J., Stanković, T., Jovanovic, M., Ramović, A., Pustenko, A., Žalubovskis, R., Pešic, M. Sulfocoumarins, Specific Carbonic Anhydrase IX and XII Inhibitors, Interact with Cancer Multidrug Resistant Phenotype through pH Regulation and Reverse P-glycoprotein Mediated Resistance. European Journal of Pharmaceutical Sciences, 2019, Vol. 138, 1.-9.lpp. ISSN 0928-0987. e-ISSN 1879-0720. Pieejams: doi:10.1016/j.ejps.2019.105012

Publikācijas valoda
English (en)