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Publikācija: Sulfocoumarins

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Nosaukums oriģinālvalodā Sulfocoumarins, Specific Carbonic Anhydrase IX and XII Inhibitors, Interact with Cancer Multidrug Resistant Phenotype through pH Regulation and Reverse P-glycoprotein Mediated Resistance
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Autori Ana Podolski-Renic
Jelena Dinić
Tijana Stanković
Mirna Jovanovic
Amra Ramović
Aleksandrs Pustenko
Raivis Žalubovskis
Milica Pešic
Atslēgas vārdi sulfocoumarins, carbonic anhydrase, triazole
Anotācija New 6-triazolyl-substituted sulfocoumarins were described as potent inhibitors of the transmembrane human carbonic anhydrase isoforms, CAIX and CAXII. These membrane associated enzymes that maintain pH and CO2 homeostasis are involved in cancer progression, invasion, and resistance to therapy. Recently, it was shown that CAXII expression associates with the expression of P-glycoprotein in multidrug resistant cancer cells. CAXII regulates P-glycoprotein activity by maintaining high intracellular pHi. In this study, the activity of three new sulfocoumarins was evaluated in three sensitive and corresponding multidrug resistant cancer cell lines with increased P-glycoprotein expression (non-small cell lung carcinoma, colorectal carcinoma and glioblastoma).
DOI: 10.1016/j.ejps.2019.105012
Hipersaite: https://www.sciencedirect.com/science/article/pii/S0928098719302751?via%3Dihub 
Atsauce Podolski-Renic, A., Dinić, J., Stanković, T., Jovanovic, M., Ramović, A., Pustenko, A., Žalubovskis, R., Pešic, M. Sulfocoumarins, Specific Carbonic Anhydrase IX and XII Inhibitors, Interact with Cancer Multidrug Resistant Phenotype through pH Regulation and Reverse P-glycoprotein Mediated Resistance. European Journal of Pharmaceutical Sciences, 2019, Vol. 138, 1.-9.lpp. ISSN 0928-0987. e-ISSN 1879-0720. Pieejams: doi:10.1016/j.ejps.2019.105012
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