Process-Related Impurities of Pazopanib

Organic Process Research & Development 2019
Svetlana Terentjeva, Dzintra Muceniece, Viesturs Lūsis

The main target of this study was to synthesize reference compounds for HPLC analysis of impurities, produced in Pazopanib synthesis. It is highly desirable that impurity standards are made available to help in developing an HPLC control method that could be suitable for use in the industrial process. To the best of our knowledge, most of these impurities are not commercially available and no synthetic methods have been reported. Potential impurities were synthesized, and their structures were established by various spectroscopy techniques.

Atslēgas vārdi
Pazopanib regioisomers alkylation 6-nitro-1H-indazole indazol-6-ylamines amination of 2,4-dichloropyrimidine process impurities
DOI
10.1021/acs.oprd.9b00117
Hipersaite
https://pubs.acs.org/doi/10.1021/acs.oprd.9b00117

Terentjeva, S., Muceniece, D., Lūsis, V. Process-Related Impurities of Pazopanib. Organic Process Research & Development, 2019, Vol. 23, No. 9, 2057.-2068.lpp. ISSN 1083-6160. e-ISSN 1520-586X. Pieejams: doi:10.1021/acs.oprd.9b00117

Publikācijas valoda
English (en)