A series of experimental tests have been carried out on three types of novel sandwich panels mainly designed for application in lightweight mobile housing. Two types of the panels are manufactured entirely from wood-based materials while the third one presents a combination of plywood for surfaces and corrugated thermoplastic composite as a core part. All sandwich panels are designed to allow rapid one-shot manufacturing. Mechanical performance has been evaluated in four-point bending comparing the data to the reference plywood board. Additionally, finite element simulations were performed to evaluate global behavior, stress distribution and provide the basis for a reliable design tool. Obtained results show sufficient mechanical characteristics suitable for floor and wall units. Compared to a solid plywood board, sandwich alternative can reach up to 42% higher specific stiffness, at the same time maintaining sufficient strength characteristics.