Total energy consumption of buildings and structures in the construction sector today accounts for 41 % of the total European Union (EU) energy consumption. For heating and air conditioning are used 85 % of total energy consumption. Therefore, one of the main ways to increasing of the heat power devices efficiency in the future – improvement of the heat exchanging equipment, which can be realized through the introduction of effective heat transferring intensifications methods. Special attention now is paid to studies of pulsating flow influence on heat transferring. Such unsteady flows can be created artificially, or may appear during the operation of the thermal energy equipment, and can be accompanied by increasing and decreasing of the heat transferring intensity. However, the influence of such a regime on a human comfort level is not enough studied. The purpose of this work is to investigate the effect of the pulsating mass flow rate of the circulating media on the thermal power of a panel heating radiator and to analyze the effect of thermal pulsations on the human comfort level. At the first stage, a type P11 steel panel radiator, with overall dimensions of 600x800 mm and operating pressure up to 10 Bar, was studied. The circulating media in the radiator is water. The average mass flow rate of the circulating media is M = 0.1 kg· s-1, the temperature head is 70 ºC, the pulsation frequency range of the circulating media is from 0 to 5 HZ. At the second stage, the radiator was installed in a model of the room in which people were located, where the influence of thermal pulsations on the level of human comfort was studied. Numerical modeling was carried out with using of the CAD/CFD complex of Solid Works/Flow Simulation software. The complete system of Navier-Stokes equations and the energy equation were solved using the k-ε turbulence model in a non-stationary formulation of the problem. Results of the numerical calculations showed that the periodic pulsating mass flow rate of the circulating media in the heating radiator, compared with the stationary mode, leads to an increase in the average heat flux of the radiator during operation by approximately 25 %. And, as a result, it leads to uncomfortable conditions in the room where people are located.