With the growing competition, many companies are merging together to get competive advantage [1]. Post-merger integration (PMI) is the process of integrating two or more organizations together in a scope of Merger & Acquisition (M&A) initiative. Current PMI research can be divided in two main parallel streams – PMI of strategy and organizational structure, and PMI of information systems (IS). However, each organization is a complex system, which should be viewed from different interrelated aspects, such as personnel, culture, infrastructure, product portfolio, processes, etc. With this, it sounds reasonable to research PMI as a holistic integration of several socio-cyberphysical systems (SCPS). This paper focuses on the existing PMI and IS PMI research literature review to summarize existing knowledge in these areas, as well as to state main questions for the future SCPS PMI research.