The transfer of learning from the classroom to an e-learning environment led to the need to find new technological and pedagogical solutions for the improvement of learners’ motivation and cognition. The objective of the transdisciplinary research is to find the most effective solutions for spaced learning in the e-learning environment and to create an information system for the implementation of spaced e-learning in the learning management system (LMS). During the research, the first prototype of spaced e-learning was implemented in the MOOC type LMS OpenEdX and brought into action with bachelor level students to clarify the usefulness of the method and the students' attitude towards it. Experience from the first prototype showed the effectiveness of the method and the need to personalize its use. The most appropriate solutions for students' needs were also identified. In the light of the data obtained, an information system (IS) for the personalization of the method was developed, for use in several kinds of LMS. Research showed the need to take personal interests into account to motivate students to use the method in the learning process. This is ensured by the developed method and information system.