In the present study occupational health and safety system and basis of the E-Health were analysed. The E-Occupational health and safety means transforming E-Health basic principles into E-Occupational health and safety context. The E-Occupational health and safety system differentiates from E-Health system as the stakeholders are different, including their interactions, hierarchy and tasks. Thus, the necessity of creating E-Occupational health and safety system is based not only on the scientific literature, but also on the level of the European and national development priorities. Estonia has a well-developed E-Health system, but not yet in the form of E-Occupational health and safety. Authors of the present paper investigated Estonian occupational health structure systematically and, based on the research results, developed the framework of E-Occupational health and safety, where stakeholders’ functions are taken into account. As a result of the study are described by stakeholders’ main activities obtained from the legislation, scientific literature and risk assessment cases. Stakeholders’ activities are arranged into the system enabling to create IT-solutions.