Silk fibroin (SF) is a fibrous protein derived from Bombyx mori cocoons, that can form natural hydrogels with good biocompatibility, mechanical strength, and relatively slow degradation time. In tissue engineering, SF is often used in combination with other biomaterials. Composite materials can be formed with bioactive ceramics, glass and polymers - synthetic or naturally occurring, such as hyaluronic acid (HA) - a glycosaminoglycan found in every person's cartilage, that is used for the production potential carriers for cell transplantation [3] and hydroxyapatite (HAp) - a naturally occurring mineral that is biocompatibile and osteoconductive. The aim of this study was to investigate the ability of silk fibroin to form novel biometarials with other polymers and HAp.