Bioaccumulation of Lead (Pb) and Its Effects on Human: a Review
Journal of Hazardous Materials Advances 2022
Samuel Collin, Amritha Baskar, Deepthi Mariam Geevarghese, Rajan Choudhary, Vladislav Lvov, Gabriel Ibrahin Tovar, Fedor Senatov, Sivasankar Koppala, Sasikumar Swamiappan, Senthil Kumar Venkatraman, Naveensubramaniam Vijayakumar, V. Kanimozhi, Muhammad Arbaaz, Sibiya Stao Jogannagari Anusha

Lead is a prevalent heavy metal that pollutes the environment and accumulates in the human body via absorption, bioavailability, bioconcentration, and biomagnification disrupts the neurological, skeletal, reproductive, hematopoietic, renal, and cardiovascular systems. Lead's distinctive physical and chemical characteristics make it ideal for a variety of uses. It has been linked to human activities for ages and is harmful to health. This review article examines the long-term health consequences of lead exposure in humans. Acute and chronic symptoms of lead poisoning include kidney, brain, reproductive organ, and CNS/PNS damage. Toxic metals have a long half-life in the bone matrix and brain (2–3 years), causing neurological problems and bone loss. The article also shows the problems of high BPb in both men and women during pregnancy. Renal system blood lead levels of 30–60 g/dL may cause kidney failure in severe circumstances. The oxidative stress that occurs in human cells has also been explored. Finally, lead poisoning and lead buildup prevention and therapy have been reviewed. The use of micronutrients and antioxidants has demonstrated a reduction in harmful effects. Adults with BPb >45 g/dL should have chelation, whereas children should receive succimer.


Atslēgas vārdi
Heavy metals, Heavy metal toxicity, Lead uptake, Lead bioavailability, Bioconcentration
DOI
10.1016/j.hazl.2022.100064
Hipersaite
https://www.sciencedirect.com/science/article/pii/S266691102200017X

Collin, S., Baskar, A., Geevarghese, D., Choudhary, R., Lvov, V., Tovar, G., Senatov, F., Koppala, S., Swamiappan, S., Venkatraman, S., Vijayakumar, N., Kanimozhi, V., Arbaaz, M., Anusha, S. Bioaccumulation of Lead (Pb) and Its Effects on Human: a Review. Journal of Hazardous Materials Advances, 2022, Vol. 7, Article number 100064. ISSN 2772-4166. Available from: doi:10.1016/j.hazl.2022.100064

Publikācijas valoda
English (en)
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