Nowadays, osteoporosis is becoming more common, affecting both young and old people. Various medications containing active substances increasing bone density, such as strontium ranelate (SrRan), can be used for the treatment. Hydrogels with anti-inflammatory and antibacterial properties have been a major research topic in the biomedical field for the past decades, thus combining antibacterial properties of ε-poly-L-lysine (ε-PL), bioactivity of hyaluronic acid (HA) and antiosteoporotic properties of SrRan novel injectable polymer hydrogels providing controlled and prolonged drug release at the target site were prepared and analysed.