Hypothesis, that optical radiation is able to alter surface electrochemical potential and due to this affect bone remodeling processes have been proposed. Besides, researches, being done beforehand, in majority used laser radiation of single wavelength; the latter usually does not match well with optical absorption bands of the bone, obtained in a series of in-vitro experiments. The goal of the present work was to evaluate in-vivo influence of the optical light of different wavelength on the bone remodeling / reconstruction process. For this, artificial defect have been made at the mandible bone of female rabbits. During operation and 10 days after surgery operation site was irradiated with optical radiation with either long (550 – 5000 nm) or short (350 – 550) wavelength. Results demonstrated that light treatment suppresses rate of healing of the bone defect for both experimental groups comparing with the control. The suppression effect is more expressed for short-wavelength irradiation.