Alkylation and arylation on the purine ring usually proceeds almost selectively at N(9) position. While there are some simple pathways to introduce alkyl substituents at N(7), the same is not true for introduction of aryl groups. The most commonly used Cu catalyzed Chan-Lam reaction and arylation with iodanes selectively give N(9) product. The few existing methods for purine N(7) arylation still provide a mixture of two isomers and are substrate dependent [4]. Hence, we decided to test various pathways towards 7-arylpurines starting from substituted pyrimidines.