Injectable Bone Cements: What Benefits the Combination of Calcium Phosphates and Bioactive Glasses Could Bring?
Bioactive Materials 2023
Oznur Demir, Dagnija Loča, A.R Boccaccini

Out of the wide range of calcium phosphate (CaP) biomaterials, calcium phosphate bone cements (CPCs) have attracted increased attention since their discovery in the 1980s due to their valuable properties such as bioac- tivity, osteoconductivity, injectability, hardening ability through a low-temperature setting reaction and mold- ability. Thereafter numerous researches have been performed to enhance the properties of CPCs. Nonetheless, low mechanical performance of CPCs limits their clinical application in load bearing regions of bone. Also, the in vivo resorption and replacement of CPC with new bone tissue is still controversial, thus further improvements of high clinical importance are required. Bioactive glasses (BGs) are biocompatible and able to bond to bone, stimulating new bone growth while dissolving over time. In the last decades extensive research has been per- formed analyzing the role of BGs in combination with different CaPs. Thus, the focal point of this review paper is to summarize the available research data on how injectable CPC properties could be improved or affected by the addition of BG as a secondary powder phase. It was found that despite the variances of setting time and compressive strength results, desirable injectable properties of bone cements can be achieved by the inclusion of BGs into CPCs. The published data also revealed that the degradation rate of CPCs is significantly improved by BG addition. Moreover, the presence of BG in CPCs improves the in vitro osteogenic differentiation and cell response as well as the tissue-material interaction in vivo.

Atslēgas vārdi
Calcium phosphate, Bioactive glass, Injectable bone cements, Bone regeneration, Calcium phosphate bone cements

Demir, O., Loča, D., Boccaccini, A. Injectable Bone Cements: What Benefits the Combination of Calcium Phosphates and Bioactive Glasses Could Bring?. Bioactive Materials, 2023, Vol. 19, 217.-236.lpp. ISSN 2452-199X. Pieejams: doi:10.1016/j.bioactmat.2022.04.007

Publikācijas valoda
English (en)
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