Calcium Phosphate Bone Cements as Local Drug Delivery Systems for Bone Cancer Treatment
Biomaterials Advances 2023
Athanasia Pylostomou, Oznur Demir, Dagnija Loča

Bone cancer is usually a metastatic disease, affecting people of all ages. Its effective therapy requires a targeted drug administration locally at the cancer site so that the surrounding healthy organs and tissues stay unharmed. Upon a thorough literature search, a tremendous number of published articles are reporting on development of calcium phosphate cements (CPCs) for the treatment of a variety of diseases, such as osteoporosis, osteoarthritis, osteomyelitis, and other musculoskeletal disorders. However, just a limited number of research employs CPCs specifically for bone cancer treatment. In this review article, we study the factors influencing the local drug release from CPCs and particularly focus on bone cancer therapy. Finally, we locate the deficiencies in the literature regarding this specific topic and propose which other perspectives should be considered and discussed in future articles.

Atslēgas vārdi
Calcium phosphate cements, Drug delivery, Bone cancer, Antineoplastic drugs, Bisphosphonates

Pylostomou, A., Demir, O., Loča, D. Calcium Phosphate Bone Cements as Local Drug Delivery Systems for Bone Cancer Treatment. Biomaterials Advances, 2023, Vol. 148, Article number 213367. ISSN 2772-9508. Pieejams: doi:10.1016/j.bioadv.2023.213367

Publikācijas valoda
English (en)
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