Since global crises humanity faces are becoming a regular phenomenon, the need to research the mechanisms for reaching business resilience has become crucial. Therefore, this paper explores the factors that influence one of the business resilience components: companies' ability to adapt to changing circumstances with minimal destructive effect during crises. The literature review revealed three domains of company adaptability factors - individual, organizational, and external. The qualitative content analysis of responses from 218 heads and owners of companies from Europe, Asia, Africa, and America enabled us to determine factors that have the most significant weight in business adaptability. The 39 categories systemized in corresponding three tables shed light on the issue of what business practitioners consider as business adaptability impacting factors based on their experiences of living and working during the Global Financial Crisis of 2007-2008, the COVID-19 pandemic worldwide and/or Russia's war in Ukraine while attempting to overcome the drastic consequences caused by them.