Since global crises humanity faces are becoming a regular phenomenon, the need to research the mechanisms for reaching business resilience has become crucial. Therefore, this paper explores the factors that influence one component of business resilience: companies’ ability to adapt to changing circumstances with minimal destructive effect during crises. The literature review revealed three domains of company adaptability factors - individual, organizational, and external. The qualitative content analysis of responses from 218 heads and owners of companies from Europe, Asia, Africa, and America enabled us to determine factors that have the most significant weight in business adaptability The three tables that systemize 49 categories provide insights into the factors that impact business adaptability, based on the experiences of business practitioners during the Global Financial Crisis of 2007-2008, the COVID-19 pandemic, and Russia's war in Ukraine.