From Classical Dualistic Antagonism to Hormone Synergy: Potential of Overlapping Action of Glucagon, Insulin and GLP-1 for the Treatment of Diabesity
Endocrine Connections 2024
Svjatoslavs Kistkins, Othmar Moser, Vitālijs Ankudovičs, Dmitrijs Bļizņuks, Timurs Mihailovs, Sergejs Lobanovs, Harald Sourij, Valdis Pīrāgs, Andreas F.H. Pfeiffer

The increasing prevalence of "diabesity," a combination of type 2 diabetes and obesity, poses a significant global health challenge. Unhealthy lifestyle factors, including poor diet, sedentary behaviour, and high stress levels, combined with genetic and epigenetic factors, contribute to the diabesity epidemic. Diabesity leads to various significant complications such as cardiovascular diseases, stroke, and certain cancers. Incretin-based therapies, such as GLP-1 receptor agonists and dual hormone therapies, have shown promising results in improving glycaemic control and inducing weight loss. However, these therapies also come with certain disadvantages, including potential withdrawal effects. This review aims to provide insights into the cross-interactions of insulin, glucagon, and GLP-1, revealing the complex hormonal dynamics during fasting and postprandial states, impacting glucose homeostasis, energy expenditure, and other metabolic functions. Understanding these hormonal interactions may offer novel hypotheses in the development of "anti-diabesity" treatment strategies. The article also explores the question of the antagonism of insulin and glucagon, providing insights into the potential synergy and hormonal overlaps between these hormones.


Atslēgas vārdi
glucagon, insulin, GLP-1, diabesity, treatment
DOI
10.1530/EC-23-0529
Hipersaite
https://ec.bioscientifica.com/view/journals/ec/aop/ec-23-0529/ec-23-0529.xml

Kistkins, S., Moser, O., Ankudovičs, V., Bļizņuks, D., Mihailovs, T., Lobanovs, S., Sourij, H., Pīrāgs, V., Pfeiffer, A. From Classical Dualistic Antagonism to Hormone Synergy: Potential of Overlapping Action of Glucagon, Insulin and GLP-1 for the Treatment of Diabesity. Endocrine Connections, 2024, Vol. 13, Article number EC-23-0529. e-ISSN 2049-3614. Available from: doi:10.1530/EC-23-0529

Publikācijas valoda
English (en)
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