Breath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography–Mass Spectrometry Analysis
International Journal of Molecular Sciences 2024
Elīna Kononova, Linda Mežmale, Inese Poļaka, Viktors Veliks, Linda Anarkulova, Ilona Vilkoite, Ivars Tolmanis, Anna Marija Leščinska, Ilmārs Stonāns, Andrejs Pčolkins, Pawel Mochalski, Mārcis Leja

The human body emits a multitude of volatile organic compounds (VOCs) via tissues and various bodily fluids or exhaled breath. These compounds collectively create a distinctive chemical profile, which can potentially be employed to identify changes in human metabolism associated with colorectal cancer (CRC) and, consequently, facilitate the diagnosis of this disease. The main goal of this study was to investigate and characterize the VOCs’ chemical patterns associated with the breath of CRC patients and controls and identify potential expiratory markers of this disease. For this purpose, gas chromatography–mass spectrometry was applied. Collectively, 1656 distinct compounds were identified in the breath samples provided by 152 subjects. Twenty-two statistically significant VOCs (p-xylene; hexanal; 2-methyl-1,3-dioxolane; 2,2,4-trimethyl-1,3-pentanediol diisobutyrate; hexadecane; nonane; ethylbenzene; cyclohexanone; diethyl phthalate; 6-methyl-5-hepten-2-one; tetrahydro-2H-pyran-2-one; 2-butanone; benzaldehyde; dodecanal; benzothiazole; tetradecane; 1-dodecanol; 1-benzene; 3-methylcyclopentyl acetate; 1-nonene; toluene) were observed at higher concentrations in the exhaled breath of the CRC group. The elevated levels of these VOCs in CRC patients’ breath suggest the potential for these compounds to serve as biomarkers for CRC. © 2024 by the authors.


DOI
10.3390/ijms25031632
Hipersaite
https://www.mdpi.com/1422-0067/25/3/1632

Kononova, E., Mežmale, L., Poļaka, I., Veliks, V., Anarkulova, L., Vilkoite, I., Tolmanis, I., Leščinska, A., Stonāns, I., Pčolkins, A., Mochalski, P., Leja, M. Breath Fingerprint of Colorectal Cancer Patients Based on the Gas Chromatography–Mass Spectrometry Analysis. International Journal of Molecular Sciences, 2024, Vol. 25, No. 3, Article number 1632. e-ISSN 1422-0067. Pieejams: doi:10.3390/ijms25031632

Publikācijas valoda
English (en)
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