The globalization of the world industry brought about de-industrialization in developed countries. Job losses in manufacturing continued between 2001 to 2011. Nowadays, the production towards less developed but low labour-cost countries continues. Therefore, in Latvia, Estonia etc., innovation in manufacturing like the garment industry, is needed. In the current paper, the possibilities for developing small enterprises (mini-factory) are presented. The focus of the study is directed to the working environment conditions in the printing of textiles. In the preliminary study for declaring the ventilation conditions in the printing room, the microclimate, noise, and physical conditions of workers were investigated in a Latvian garment laboratory. The appropriate room dimensions were settled. After that, I an Estonian laboratory, the printing of textiles using water-based dyes was used. The chemicals in the working environment air were measured using a portable FTIR-NIR spectrometer. The lighting of workplaces, noise, humidity and temperature level during printing of the chemical CH2BrCl from the dye correspond to the norms. The most important in garment printing is to follow the local ventilation, not allowing the chemical pollution into the area of the breathing zone of the worker. Add the additional lights if needed, check the local and overall ventilation system, place adjustable chairs with 5 wheels near the sewing machines, get rid of unnecessary wires, and organize an ergonomic workplace.