Characterization of Tissue after Impalntation of Biomaterials Covered by Stem Cells in Sub Cutis of Experimental Animals

Journal of Tissue Engineering and Regenerative Medicine 2012
Māra Pilmane, Ģirts Šalms, Ilze Šalma, Andrejs Skaģers, Jānis Ločs, Vita Šteinberga, Līga Bērziņa-Cimdiņa

Mesenchymal stem cells (MSC) influence the tissue regeneration. Our aim was detection of soft tissue changes in subcutis of experimental animals after covered by MSC different type biomaterial. Material was obtained from six rabbit 8 weeks after hydroxyapatite (HAp) granuli and tablets seeded by MSC implantation. Soft tissue around MSC/biomaterial implants are characterized by decreased cellular stress, selective apoptosis and stimulation of cellular proliferation. Type of HAp material does not play a role in expression of tissue factors.

Keywords
tissue, hydroxyapatite, mesenchymal stem cells, biomaterial
DOI
10.1002/term.1586

Pilmane, M., Šalms, Ģ., Šalma, I., Skaģers, A., Ločs, J., Zālīte, V., Bērziņa-Cimdiņa, L. Characterization of Tissue after Impalntation of Biomaterials Covered by Stem Cells in Sub Cutis of Experimental Animals. Journal of Tissue Engineering and Regenerative Medicine, 2012, Vol.6, Iss.s1, pp.221-222. ISSN 1932-6245. e-ISSN 1932-7005. Available from: doi:10.1002/term.1586

Publication language
English (en)